Skrining Fitokimia dan Aktivitas Antikoagulan Sari Buah Melon (Cucumis melo L) Secara In Vivo

Anticoagulants are drugs used to inhibit the development and enlargement of a blood clot. Melon is known contain adenosime that function stop clotting cell chip. This study aims identify secondary metabolites contained in melon juice, fruit juice anticoagulant activity vivo melon, look for an effective dose as potential compared with aspirin. A total 15 male mice were divided into 5 groups, i.e. groups 12.9 g/kg BW, group 25.8 51.5 positive control negative group. The sample given once day orally measured hours 3, 6 9 after administration. Anticoagulant effect was tested by using parameters bleeding time coagulation time. results showed BW may increase From these it can be seen has activity. Based on statistical test variation doses very significantly affect time.Keywords : anticoagulant, time,